![\"JosipMILJKOVIC-2025\"](\"https:\/\/veterinarska-stanica-journal.hr\/wp-content\/uploads\/2025\/06\/JosipMILJKOVIC-2025.jpg\")
<\/p>\n<\/p>\n
Josip Miljkovi\u0107<\/strong>* and Dra\u017een \u0110uri\u010di\u0107<\/strong><\/p>\n <\/a><\/p>\n <\/a> ▲<\/a><\/p>\n Two cases of local skin reactions to intramuscular application of enrofloxacin in a reticulated python (Malayopython reticulatus<\/em>) (6 years, 5.5 kg) and a Burmese python (Python bivitatus<\/em>) (3 years, 25 kg) are presented. The reticulated python was treated for a swelling of the upper jaw, while the Burmese python had respiratory symptoms. The first python was treated with meloxicam for 7 days, but since the swelling did not go down, the local veterinarian consulted a reptile expert. Instead of the recommended marbofloxacin, the animal received an intramuscular injection of enrofloxacin, and swelling and a sterile abscess appeared at the injection site, with local pinkish skin discolouration. After marbofloxacin therapy was continued, the swelling disappeared. Key words:<\/strong> Burmese python, discoloration, enrofloxacin, intramuscular administration, reticulated python, skin reaction<\/em><\/p><\/blockquote>\n <\/a> ▲<\/a><\/p>\n The non-venomous snakes of the genera Python<\/em> and Malayopython<\/em> belong to the family Pythonidae (with other nine genera) and live in Africa and Asia. They feed by wrapping themselves around the prey, which then dies from suffocation, internal bleeding and cardiac arrest.<\/p>\n The Burmese python (Python bivittatus<\/em>, Kuhl, 1820) is an endangered species (classified as vulnerable on the IUCN Red List) native to Southeast Asia, while in Florida, USA it is considered an invasive species following its release into the wild by owners unable to care for their pets (Stuart et al<\/em>., 2019). Females are longer (3.5-4.5 m) and heavier (30-40 kg) than males. Dwarf forms are found on the islands of Java, Bali and Sulawesi, with an average length of 2-2.5 metres. Burmese pythons are mainly nocturnal rainforest dwellers.<\/p>\n The reticulated python (Malayopython reticulatus<\/em>, Schneider, 1801) is a species of python and the longest snake in the world, native to South and Southeast Asia. The Burmese python and the reticulated python, together with the ball python, are very popular in the pet trade, and numerous mutations (morphs) with different colours and patterns have been bred through selection. In captivity, snakes are often kept in inappropriate conditions, which can lead to chronic stress and various diseases (Mart\u00ednez-Silvestre, 2014; Van Waeyenberge et al<\/em>., 2018; Warwick et al<\/em>., 2021). Diseases and other health problems in captive reptiles are usually the result of poor breeding management and are often caused by changes in environmental conditions (overcrowding, inappropriate temperature, humidity, light, nutrition and poor hygiene), but also by interactions with newly acquired animals. Enrofloxacin is used in veterinary medicine as an antibacterial agent against numerous Gram-positive and Gram-negative bacteria, mainly due to the inhibition of bacterial gyrase and topoisomerase IV, enzymes that facilitate the processes of DNA replication, recombination and gene expression (Grabowski et al<\/em>., 2022). Ciprofloxacin is the main active metabolite of enrofloxacin conversion, which likely occurs only in the liver (Waxman et al<\/em>., 2014; Agius et al<\/em>., 2020; Foster et al<\/em>., 2023). <\/a> ▲<\/a><\/p>\n Two pythons, a purple albino reticulated python (Malayopython reticulatus<\/em>), 6 years old and weighing 5.5 kg, and a granite het albino Burmese python (Python bivitatus<\/em>), 3 years old and weighing 25 kg, are shown in these cases. The owner of these snakes is located in Split, Croatia. In both cases, the animals were clinically examined and treated in various local veterinary clinics, so data on possible sampling or additional tests (e.g., blood tests, biochemical indicators, x-rays, ultrasound, etc.) was not accessible.<\/p>\n <\/a> ▲<\/a><\/p>\n After the owner noticed a swelling on the head (upper jaw) of the reticulated python (Figure 1), professional help was requested.<\/p>\n The swelling most likely occurred as a result of repeatedly hitting the head against the terrarium glass. After the first dose, Enroxyl was discontinued, and treatment with Marbocyl was continued for 7 days. Thereafter, the swelling on the jaw disappeared, but the discoloration (white patch) at the site of the single application of enrofloxacin is still present even after 3 months (Figure 3).<\/p>\n In 2019, a 3-year-old Burmese python had respiratory symptoms (heavy breathing with open mouth), after which it received enrofloxacin (Baytril, Bayer Animal Health, Leverkusen, Germany) and bromhexine hydrochloride (Bisolvon, Boehringer Ingelheim, Ingelheim am Rhein, Germany) intramuscularly for 14 days. Sterile abscesses and skin discolouration occurred at 3-4 sites of enrofloxacin application. Initially, the scales around the site of enrofloxacin application became paler and matte (Figure 4).<\/p>\n At these sites, it appeared as though the scales had melted, and a slight spherical bulge with a hard-elastic consistency could still be palpated even five years after administration (Figure 5).<\/p>\n The treatment was carried out at another local clinic.<\/p>\n <\/a> ▲<\/a><\/p>\n Almost all veterinary medical preparations used to treat reptiles are not registered for that group of animals (i.e.<\/em>, they are mostly used off-label). Due to the specific anatomical, physiological and behavioural differences between species, it is more difficult to select a suitable antimicrobial agent for reptiles than for mammals. Relatively few pharmacokinetic and pharmacodynamic studies have been conducted on the use of antimicrobial agents in reptiles, and in only a small number of species, so doses are usually empirically derived or prescribed from a different species or groups of reptiles (Jacobson, 1999; Gibbons, 2014). Agius et al<\/em>. (2020) used enrofloxacin for the treatment of systemic infections in Asian house geckos, while Pees et al<\/em>. (2008) found that enrofloxacin can be successfully used to treat lung disease in sea turtles and Indian pythons. In our case, pneumonia in a Burmese python was also successfully treated with enrofloxacin, after which the animal made a full recovery. According to Lewbart (2001), the quinolone compound enrofloxacin (Baytril, Bayer Animal Health, Germany) appears to be safe and effective in reptiles and can be administered intramuscularly (IM), subcutaneously (SC) or orally (PO) at a dose of 5\u201310 mg\/kg\/day for 7\u201321 days, and can be diluted with sterile physiological solution. Similar to Young et al<\/em>. (1997), enrofloxacin can be administered to treat Pseudomonas<\/em> spp. infection in young Burmese pythons at a dose of 10 mg\/kg IM, followed by 5 mg\/kg every 48 hours (Young et al<\/em>., 1997), while the Merck Veterinary Manual recommends administering a PO dose of 5\u201310 mg\/kg\/day after the first IM application, as the injection causes necrosis at the injection site (Aiello and Moses, 2016). In the Carpenters\u2019 Exotic Animal Formulary (Carpenter, 2018) enrofloxacin is prescribed for most reptile species at a dose of 5\u201310 mg\/kg every 24 hours PO, SC, IM or intracelomic (Ice), but IM administration is painful and can cause skin discolouration or tissue necrosis when administered subcutaneously. In our cases, discolouration occurred even though enrofloxacin was administered intramuscularly and not subcutaneously, as stated in the previous indications. When enrofloxacin is administered SC, it is recommended to dilute it with sterile saline solution. For Pseudomonas<\/em> infections in reticulated pythons, intramuscular administration of enrofloxacin is recommended at a dose of 6.6 mg\/kg IM every 24 hours or 11 mg\/kg IM every 48 hours (Carpenter, 2018), while for Burmese pythons, rattlesnakes and pit pythons, a dose of 10 mg\/kg is recommended every 48 hours (Carpenter, 2018; 2023).<\/p>\n <\/a> ▲<\/a><\/p>\n Intramuscular application of enrofloxacin in the Burmese python and the reticulated python may result in the formation of a sterile abscess at the injection site and long-term discolouration of the skin at this site. Some prescriptions warn of possible skin discolouration, but only after subcutaneous administration of enrofloxacin, although this is not supported by the literature reference for snakes but for other groups of reptiles.<\/p>\n <\/a> 1.\tAGIUS, J. E., B. KIMBLE, M. GOVENDIR, K. ROSE, C.-L. POLLARD and D. N. PHALEN (2020): Pharmacokinetic profile of enrofloxacin and its metabolite ciprofloxacin in Asian house geckos (Hemidactylus frenatus) after single-dose oral administration of enrofloxacin. Vet. Anim. Sci. 9, 100116. 10.1016\/j.vas.2020.100116 <\/a> ▲<\/a><\/p>\n Prikazana su dva slu\u010daja lokalne ko\u017ene reakcije na intramuskularnu primjenu enrofloksacina u mre\u017eastog pitona (Malayopython reticulatus<\/em>) (6 godina, 5,5 kg) i burmanskog pitona (Python bivitatus<\/em>) (3 godine, 25 kg). Mre\u017eastom pitonu lije\u010dena je oteklina na gornjoj \u010deljusti, dok je burmanski piton imao respiratorne simptome. Prvog pitona lije\u010dili su 7 dana meloksikamom, budu\u0107i da oteklina nije nestala lokalni je veterinar zatra\u017eio savjet stru\u010dnjaka za gmazove s Veterinarskog fakulteta Sveu\u010dili\u0161ta u Zagrebu. Umjesto preporu\u010denog marbocilina, \u017eivotinja je lije\u010dena intramuskularnu injekciju enrofloksacina, nakon \u010dega se pojavio otok i sterilni apsces s ru\u017ei\u010dastom lokaliziranom diskoloracijom ko\u017ee. Klju\u010dne rije\u010di:<\/strong> burmanski piton, diskoloracija, enrofloksacin, intramuskularna primjena, ko\u017ena reakcija, mre\u017easti piton<\/em><\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":" Josip Miljkovi\u0107* and Dra\u017een \u0110uri\u010di\u0107 Josip MILJKOVI\u0106*, DVM, (Corresponding author. E-mail: jmiljkovic@vef.unizg.hr), Dra\u017een \u0110URI\u010cI\u0106, DVM, PhD, Assistant Professor, Faculty of<\/p>\n","protected":false},"author":8,"featured_media":0,"menu_order":2,"comment_status":"closed","ping_status":"open","template":"","format":"standard","meta":{"footnotes":""},"categories":[35],"tags":[2617,2618,2619,2620,2621,2622],"issuem_issue":[2611],"ppma_author":[65],"class_list":["post-8564","article","type-article","status-publish","format-standard","hentry","category-professional-paper","tag-burmese-python","tag-discoloration","tag-enrofloxacin","tag-intramuscular-administration","tag-reticulated-python","tag-skin-reaction","issuem_issue-veterinarska-stanica-56-6"],"yoast_head":"\n
\nJosip MILJKOVI\u0106<\/strong>*, DVM, (Corresponding author. E-mail: jmiljkovic@vef.unizg.hr), Dra\u017een \u0110URI\u010cI\u0106<\/strong>, DVM, PhD, Assistant Professor, Faculty of Veterinary Medicine University of Zagreb, Croatia<\/div>\n![\"\"](\"https:\/\/veterinarska-stanica-journal.hr\/wp-content\/uploads\/2021\/03\/pdf.png\")
<\/a>https:\/\/doi.org\/10.46419\/vs.56.6.1<\/a><\/div>\n<\/p>\n\nAbstract<\/a>Introduction<\/a>Materials and methods<\/a>Presentation of cases<\/a>Discussion<\/a>Conclusion<\/a>References<\/a>Sa\u017eetak<\/a><\/span><\/div>\n<\/div>\n\n
Abstract<\/h2>\n
\n
\nThe white spotpatch at the site of the single application of enrofloxacin is still present after 3 months. The Burmese python received enrofloxacin and bromhexine hydrochloride intramuscularly for 14 days. Sterile abscesses and skin discolouration occurred at 3-4 sites of enrofloxacin application. Initially, the scales around the site of enrofloxacin application became pale and matte, later appearing as though the scales had melted or fused. Even 5 years later, a slight spherical bulge with a hard-elastic consistency can be felt. The treatment was carried out in another local clinic.
\nIntramuscular application of enrofloxacin in pythons can lead to the formation of a sterile abscess at the injection site and long-term discolouration of the skin above that site, although some prescriptions warn of possible skin discoloration, but only after subcutaneous administration of enrofloxacin.<\/p>\nIntroduction<\/h2>\n
\n
\nThey grow to between 2.5 and 6.5 metres in length and weigh up to 75 kg (Barker et al<\/em>., 2015). Of the three subspecies, two are dwarf subspecies (M. r. jampeanus<\/em> and M. r. saputrai<\/em>) that originate from different islands of the Sulawesi archipelago (Auliya et al<\/em>., 2002).<\/p>\n
\nPotential pathogens of diseases in reptiles can be microorganisms (viruses, bacteria, fungi, etc.) and parasites, physical or chemical (cold, heat, toxins, etc.), mechanical (injuries, etc.) agents, and nutritional deficiencies (Mader, 1996; O\u2019Rourke and Lertpiriyapong, 2015). Bacterial diseases in reptiles are successfully treated with antimicrobial preparations. Unfortunately, bacteria isolated from reptiles show varying degrees of resistance to most antimicrobial agents, including cephalosporins, penicillins, macrolides, lincosamides, tetracyclines, etc., while resistance to quinolones, chloramphenicol, and sulfonamides is less common (Cristina et al<\/em>., 2022). Quinolones, especially marbofloxacin and enrofloxacin are commonly the drugs of choice once antimicrobial resistance has been identified.<\/p>\n
\nSide effects or adverse effects of enrofloxacin use have been reported in numerous animal species, manifested as an inflammatory reaction at the injection site and changes in the skeleton (e.g. arthropathies, destruction and degeneration of articular cartilage, damage to tendons, etc.), reproductive system (e.g. reduced mobility and sperm production, increased mortality of embryos, reduced number of oocytes, etc.), nervous system, and immune system, but most often depending on the dose and the frequency of antibiotic use (Sarkozy, 2001; Bidell and Lodise, 2016; Hruba et al<\/em>., 2019; Khusro et al<\/em>., 2021; Grabowski et al<\/em>., 2022).
\nEnrofloxacin is also used to control bacterial infections in exotic animals (Mitchell, 2006), as it is rapidly resorbed after intramuscular, subcutaneous or oral administration in most reptile species and has a high bioavailability (Helmick et al<\/em>., 2004).<\/p>\nMaterials and methods<\/h2>\n
\nPresentation of cases<\/h2>\n
\nCase report 1:<\/h3>\n
![\"Figure01-Local-skin\"](\"https:\/\/veterinarska-stanica-journal.hr\/wp-content\/uploads\/2025\/06\/Figure01-Local-skin.jpg\")
\nTreatment with the non-steroidal anti-inflammatory drug meloxicam (Metacam, Boehringer Ingelheim Animal Health, Lyon, France) for 7 days was initiated immediately. Since the swelling did not subside, the local veterinarian sought the advice of a reptile expert from the Faculty of Veterinary Medicine, University of Zagreb, who recommended antibiotic therapy with marbofloxacin at the recommended dosage. However, this drug was not available to the veterinarian, so the animal was given an intramuscular injection of enrofloxacin (Enroxyl, Krka, Novo Mesto, Slovenia) instead of marbofloxacin.
\nThe next day after enrofloxacin therapy, a sterile abscess (Figure 2), swelling and a change in skin colour (pink patch), appeared and persisted for 2 months.<\/p>\n![\"Figure02-Local-skin\"](\"https:\/\/veterinarska-stanica-journal.hr\/wp-content\/uploads\/2025\/06\/Figure02-Local-skin.jpg\")
![\"Figure03-Local-skin\"](\"https:\/\/veterinarska-stanica-journal.hr\/wp-content\/uploads\/2025\/06\/Figure03-Local-skin.jpg\")
Case report 2:<\/h3>\n
![\"Figure04-Local-skin\"](\"https:\/\/veterinarska-stanica-journal.hr\/wp-content\/uploads\/2025\/06\/Figure04-Local-skin.jpg\")
![\"Figure05-Local-skin\"](\"https:\/\/veterinarska-stanica-journal.hr\/wp-content\/uploads\/2025\/06\/Figure05-Local-skin.jpg\")
Discussion<\/h2>\n
\nConclusion<\/h2>\n
\n
\nReferences<\/strong> [… show]<\/span><\/a><\/span><\/p>\n ▲<\/a><\/p>\n
\n2.\tAIELLO, S. E. and M. A. MOSES (2016): The Merck\u2019s veterinary manual. 11th ed. Whitehouse Station, N. J., Merck and Co, Whiley.
\n3.\tAULIYA, M. A., P. MAUSFELD, A. SCHMITZ and W. B\u00d6HME (2002): Review of the reticulated python (Python reticulatus Schneider, 1801) with the description of new subspecies from Indonesia. Sci. Nat. 89, 201-213. 10.1007\/s00114-002-0320-4
\n4.\tBARKER, D. G., T. M. BARKER, M. A. DAVIS and G. W. SCHUETT (2015): A review of the systematics and taxonomy of Pythonidae: an ancient serpent lineage. Zool. J. Linn. Soc. 175, 1-19. 10.1111\/zoj.12267
\n5.\tBIDELL, M. R. and T. P. LODISE (2016): Fluoroquinolone-Associated Tendinopathy: Does Levofloxacin Pose the Greatest Risk? Pharmacotherapy 36, 679-693. 10.1002\/phar.1761.
\n6.\tCARPENTER, J. W. (2018): Exotic Animal Formulary. Fifth ed. St. Louis, Elsevier Publishers, p. 84.
\n7.\tCARPENTER, J. W. (2023): Exotic Animal Formulary. Sixth ed. St. Louis, Elsevier Publishers, Pp. 104-106.
\n8.\tCRISTINA, R. T., R. KOCSIS, J. D\u00c9GI, F. MUSELIN, E. DUMITRESCU, E.TIRZIU, V. HERMAN, A. P. DARAU and I. OPRESCU (2022): Pathology and Prevalence of Antibiotic-Resistant Bacteria: A Study of 398 Pet Reptiles. Animals 12, 1279. 10.3390\/ani12101279
\n9.\tFOSTER, J. D., M. ABOURAYA, M. G. PAPICH and N. A. MUMA (2023): Population pharmacokinetic analysis of enrofloxacin and its active metabolite ciprofloxacin after intravenous injection to cats with reduced kidney function. J. Vet. Intern. Med. 37, 2230-2240. 10.1111\/jvim.16866
\n10.\tGIBBONS, P. M. (2014): Advances in reptile clinical therapeutics. J. Exot. Pet Med. 23, 21-38. 10.1053\/j.jepm.2013.11.007
\n11.\tGRABOWSKI, \u0141., L. GAFFKE, K. PIERZYNOWSKA, Z. CYSKE, M. CHOSZCZ, G. W\u0118GRZYN and A. W\u0118GRZYN (2022): Enrofloxacin\u2014The Ruthless Killer of Eukaryotic Cells or the Last Hope in the Fight against Bacterial Infections? Int. J. Mol. Sci. 23, 3648. 10.3390\/ijms23073648
\n12.\tHELMICK, K. E., M. G. PAPICH, K. A. VLIET, R. A. BENNETT and E. R. JACOBSON (2004): Pharmacokinetics of Enrofloxacin after Single-Dose Oral and Intravenous Administration in the American Alligator (Alligator mississippiensis) J. Zoo Wildl. Med. 35, 333-340. doi.org\/10.1638\/03-002.
\n13.\tHRUBA, H., E. E. E. ABDELSALAM, N. ANISIMOV, et al. (2019): Reproductive Toxicity of Fluoroquinolones in Birds. BMC Vet. Res. 15, 209. 10.1186\/s12917-019-1957-y.
\n14.\tKHUSRO, A., C. AARTI, G. BUEND\u00cdA-RODRIGUEZ, M. V. ARASU, N. A. AL-DHABI and A. BARBABOSA-PLIEGO (2021): Adverse Effect of Antibiotics Administration on Horse Health: An Overview. J. Equine Vet. Sci. 97, 103339. 10.1016\/j.jevs.2020.103339
\n15.\tJACOBSON, E. R. (1999): Antimicrobial Drug Use in Reptiles. In book: Current Veterinary Therapy XIII. chapter: Antibiotic therapy for reptiles. Small Animal Practice, Publisher: Saunders Ed: Bonagura, pp. 581-592.
\n16.\tLEWBART, G. (2001): Reptile Formulary. Atlantic Coast Veterinary Conference, 2001.
\n17.\tMADER, D. M. (1996): Reptile Medicine and Surgery. W.B. Saunders Company, Philadelphia, PA., p. 512
\n18.\tMART\u00cdNEZ-SILVESTRE, A. (2014): How to assess stress in reptiles. J. Exot. Pet Med. 23, 240-243. 10.1053\/j.jepm.2014.06.004.
\n19.\tMITCHELL, M. A. (2006): Enrofloxacin. J. Exot. Pet Med. 15, 66\u201369. https:\/\/doi.org\/ 10.1053\/j.jepm.2005.11.011.
\n20.\tO\u2019ROURKE, D. P. and K. LERTPIRIYAPONG (2015): Chapter 19 \u2013 Biology and Diseases of Reptiles. In: Laboratory Animal Medicine (Third Ed.). American College of Laboratory Animal Medicine, USA, 967-1013. 10.1016\/B978-0-12-409527-4.00019-5
\n21.\tPEES, M., I. KIEFER, G. OECHTERING and M.-E. KRAUTWALD-JUNGHANNS (2008): Computed Tomography for the Diagnosis and Treatment Monitoring of Bacterial Pneumonia in Indian Pythons (Python Molurus). Vet. Rec. 163, 152-156. 10.1136\/vr.163.5.152.
\n22.\tPOAPOLATHEP, S., M. GIORGI, N. CHAIYABUTR, C. CHOKEJAROENRAT, N. KLANGKAEW, N. PHAOCHOOSAK, T. WONGWAIPAIROTE and A. POAPOLATHEP (2020): Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in freshwater crocodiles (Crocodylus siamensis) after intravenous and intramuscular administration. J. Vet. Pharmacol. Ther. 43, 19-25. 10.1111\/jvp.12791
\n23.\tSARKOZY, G. (2001): Quinolones: a class of antimicrobial agents. Vet. Med. Czech 46, 257-274. 10.17221\/7883-VETMED.
\n24.\tSTUART, B., T. Q. NGUYEN, N. THY, L. GRISMER, T. CHAN-ARD, D. ISKANDAR, E. GOLYNSKY and M. W. LAU (2019): Python bivittatus. IUCN Red List of Threatened Species. 2019: e.T193451A151341916.
\n25.\tVAN WAEYENBERGE, J., J. AERTS, T. HELLEBUYCK, F. PASMANS and A. MARTEL (2018): Stress in wild and captive snakes: quantification, effects and the importance of management. Vlaams Diergeneeskd. Tijdschr. 87, 59-65.
\n26.\tWARWICK, C., R. GRANT, C. STEEDMAN, et al. (2021): Getting It Straight: Accommodating Rectilinear Behavior in Captive Snakes\u2014A Review of Recommendations and Their Evidence Base. Animals 11, 1459. 10.3390\/ani11051459
\n27.\tWAXMAN, S., A. P. PRADOS, J. J. DE LUCAS, M. I. SAN ANDR\u00c9S, P. REGNER, V. C. DE OLIVEIRA, A. DE ROODT and C. RODR\u00cdGUEZ (2014): Pharmacokinetic Behavior of Enrofloxacin and Its Metabolite Ciprofloxacin in Urutu Pit Vipers (Bothrops alternatus) after Intramuscular Administration. J. Zoo Wildl. Med. 45, 78\u201385. 10.1638\/2013-0131R.1.
\n28.\tYOUNG, L. A., J. SCHUMACHER, M. G. PAPICH and E. R. JACOBSON (1997): Disposition of enrofloxacin and its metabolite ciprofloxacin after IM injection in juvenile Burmese pythons (Python molurus bivittatus). J. Zoo Wildl. Med. 28, 71-79.
\n<\/em><\/p>\n<\/div>\n\n
Lokalna ko\u017ena reakcija na intramuskularnu primjenu enrofloksacina u pitona<\/h2>\n
\nJosip MILJKOVI\u0106<\/strong>, dr. med. vet., dr. sc. Dra\u017een \u0110URI\u010cI\u0106<\/strong>, dr. med. vet., docent, Veterinarski fakultet Sveu\u010dili\u0161ta u Zagrebu, Hrvatska<\/div>\n
\n
\nNakon nastavka terapije marbofloksacinom otok je nestao. Bijela mrlja na mjestu jednokratne primjene enrofloksacina bila je i dalje prisutna nakon tri mjeseca. Burmanski piton primao je enrofloksacin i bromheksin hidroklorid intramuskularno 14 dana.
\nNa 3-4 mjesta primjene enrofloksacina pojavili su se sterilni apscesi i promjena boje ko\u017ee. Prvo su ljuskice oko mjesta aplikacije enrofloksacina poblijedjele i bez sjaja, a kasnije je izgledalo kao da su se ljuskice otopile ili spojile. I danas, 5 godina poslije, mo\u017ee se napipati blago kuglasto ispup\u010denje tvrdo-elasti\u010dne konzistencije. Lije\u010denje je provedeno u drugoj lokalnoj klinici. Intramuskularna primjena enrofloksacina u pitona mo\u017ee prouzro\u010diti stvaranje sterilnog apscesa na mjestu uboda kao i dugotrajnu promjenu boje ko\u017ee iznad toga mjesta. Neke upute upozoravaju na mogu\u0107u promjenu boje ko\u017ee, ali tek nakon subkutane primjene enrofloksacina.<\/p>\n